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Yale University School of Medicine

Leadership

Principal Investigator: Jeptha P. Curtis, MD
Principal Investigator: Harlan M. Krumholz, MD, SM
Project Leader: Jersey Chen, MD, MPH
Research Associate: Karl Minges, MPH
Research Assistant: Deirdre McGonigle, BA

Contact

1 Church Street
Suite 200
New Haven, CT 06510
(203) 764-5700
ccor@yale.edu

Summary

In 2010, the National Heart, Lung and Blood Institute established a Center for Cardiovascular Outcomes Research at Yale University to provide a research infrastructure to develop a national surveillance program for cardiovascular care and outcomes. This venture will allow the opportunity to examine current care patterns and treatment outcomes, identify best practices, evaluate cost-effectiveness, and develop and refine tools for measuring outcomes. CCOR at Yale seeks to better understand the patterns and systems of care that lead to improved patient outcomes through two allied projects, ENCORE and TOP PCI.

CCOR Project 1
ENCORE – Examining Novel Cardiovascular Outcomes and Regional Effects

Aim 1. To characterize hospital and regional (hospital referral region (HRR)) performance and patient-level outcomes, assess patient, organizational and regional time trends, and determine factors associated with performance and¬ improvement, defined by the CMS publicly reported measures (AMI, HF, PCI and ICD), as well as other cardiovascular conditions, tests and procedures, cardiovascular risk factors and control conditions.

Aim 2. To investigate hospital and regional performance and patient-level outcomes using novel measures that focus on a longer episode of care (1-year mortality measures for patients hospitalized with cardiovascular conditions, tests and procedures, cardiovascular risk factors and control conditions) and population-based hospitalization rates (HRR hospitalization rates for cardiovascular conditions and procedures, cardiovascular risk factors and control conditions).

Aim 3. To characterize the costs of care for cardiovascular conditions and procedures, cardiovascular risk factors and control conditions, during the index hospitalization, in the first 30 days and 1 year after admission, and investigate how costs and payments relate to patient outcomes and hospital and regional performance (30-day and 1-year risk-standardized mortality and 30-day readmission).

CCOR Project 2
TOP PCI (Translating Outstanding Performance in PCI)

Specific Aim 1. To develop hypotheses concerning the hospital organizational strategies (enabling structures, processes, hospital internal environments) associated with exceptionally low risk-standardized 30-day mortality and readmission rates for patients undergoing PCI.

Specific Aim 2. To survey hospitals in order to test hypotheses about which specific hospital organizational strategies are associated with lower risk-standardized 30-day mortality and readmission rates for patients undergoing PCI.

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